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Mekala, P.
- Antioxidant Properties of Ocimum sanctum in Broilers Treated with High Doses of Gentamicin
Abstract Views :537 |
PDF Views:550
Authors
Affiliations
1 Department of Veterinary Pharmacology and Toxicology, Veterinary College and Research Institute, Namakkal, Tamilnadu, Pin code- 637 002, IN
1 Department of Veterinary Pharmacology and Toxicology, Veterinary College and Research Institute, Namakkal, Tamilnadu, Pin code- 637 002, IN
Source
Indian Journal of Drugs and Diseases, Vol 1, No 6 (2012), Pagination: 143-146Abstract
The present research work was carried out to study the antioxidant effect of Ocimum sanctum in broilers exposed to high doses of gentamicin, which is common in poultry practice of Tamilnadu. Two hundred and seventy day old broiler chicks of either sex were randomly divided into nine treatment groups of 10 each with three replicates. Different doses of gentamicin (30 mg/kg&50 mg/kg) single intramuscular injection, different inclusion level of Ocimum sanctum crude extract (1%&2 %) in feed and their combinations were tested. The results of the study revealed that gentamicin treatment produced significant increase in the lipid peroxidation level, and significant decrease in the antioxidant enzymes viz. superoxide dismutase and glutathione peroxidase. Ocimum sanctum inclusion showed significant reversal in all the above parameters, which clearly supports its free radical scavenging property when co-administered with high doses of gentamicin.Keywords
Antioxidant, Broiler Chicks, Ocimum sanctum, GentamicinFull Text
References
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- Gupta SK, Prakash J and Srivastava S (2002) Validation of traditional claim of Tulsi, Ocimum sanctum Linn. as a medicinal plant. Indian J. Exp. Biol.40, 765-773.
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- Ramasamy L, Ling KY, Josepovitz C, Levine R and Kaloyanides GJ (2009) Effect of gentamicin on lipid peroxidation in rat renal cortex.Biol. Pharm. Bull. 32, 61-67.
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- Tabassum I, Siddiqui ZN and Rizvi SJ (2009) Protective effect of Ocimum sanctum on lipid peroxidation, nucleic acids and protein against restraint stress in male albino rats. Biol. Med.1(2), 42-53.
- Vara Prasad Reddy LSS, Thangavel A, Leela V and NarayanaRaju KVS (2007) Effect of dietary supplementation of tulasi (Ocimum sanctum) and selenium on lipid peroxidation levels and growth rate in broiler chickens. Tamilnadu J. Vet. Anim. Sci. 3(3), 144-149.
- Immunomodulatory Effect of Ocimum sanctum in Broilers Treated with High Doses of Gentamicin
Abstract Views :416 |
PDF Views:512
Authors
Source
Indian Journal of Drugs and Diseases, Vol 1, No 5 (2012), Pagination: 109-112Abstract
The purpose of the study is to evaluate the immunomodulatory effect of Ocimum sanctum in broilers exposed to high dose of gentamicin which is common in poultry practice of Tamil Nadu. Two hundred and seventy day old broiler chicks of either sex were randomly divided into nine groups of 10 each with three replicates. Different doses of gentamicin (30mg/kg &50mg/kg) single intramuscular injection, different inclusion level of Ocimum sanctum crude extract (1 and 2 %) in feed and their combinations were tested. The results of the study revealed that gentamicin treatment produced significant reduction in serum total protein, albumin and globulin and numerical decrease in HI titre against Newcastle vaccine. The groups treated with Ocimum sanctum alone showed significant increase in all the above parameters. Dose dependent increase in all the parameters were noticed in the combination groups which clearly supports the immunoprotective effect of Ocimum sanctum.Keywords
Ocimum sanctum, Gentamicin, Immunomodulation, BroilerFull Text
References
- Alexander DJ (1988) Newcastle disease diagnosis. Newcastle disease, 1stedn. Kluwar Academic Pub, Boston. pp: 98-160.
- Buss WC, Robert Kauten and Keith Piatt M (1985) Inhibitory effects of gentamicin and ethacrynic acid on mammalian microsomal protein synthesis. J. Antimicrob. Chemother.15, 105-113.
- Mediratta PK, Dewan V, Bhattacharya SK, Gupta VS, Maiti S and Sen P (1998) Effect of Ocimum sanctum Linn. on humoral immune responses. Indian J. Med. Res. 87,384-388.
- Mode SG, Funde, ST, Waghmare SP and Kolte, AY (2009) Effect of herbal immunomodulator on body weight gain in immunosuppressed broiler birds.Vet. World. 2(7), 269-270.
- Mukherjee R, Das PK and Ram GC (2005) Immunotherapeutic potential of Ocimum sanctum Linn.Bovine subclinical mastitis.Rev. Vet. Sci. 79(1), 37-43.
- Prakash (2008) Protective effect of Ocimum sanctum on lead intoxicated cockerels. The J. Pharm. Exp. Therap. 232(1), 48- 55.
- Saleemi MK, Khan MZ, JavedI and Khan A (2009) Pathological effects of gentamicin administered intramuscularly to day-old broiler chicks. Exp. Toxicol. Pathol. 61, 425-432.
- Seethalakshmi B, Narasappa AP and Kenchaveerappa S (1982) Protective effect of Ocimum sanctum in experimental liver injury in albino rats. Indian J. Pharmacol. 14, 63-70.
- Singh S, Gupta M and Gautam S (2010) Adaptogenic potential of herbal immunomodulator as new therapeutic approach to combat swine influenza A/H1N1 crisis. J. Clin. Diag. Res. 4, 3003-3005.
- Snedecor GW and Cochran WG (1989) Statistical methods, 8thEdn.IOWA state Univ. Press. Ames.
- Varley H, Gowenback AH and Bell M (1980) Practical clinical biochemistry. 5thEdn.William Hiremann medical books Ltd., London. pp: 550-555.
- Immunomodulatory Effect of Withania Somnifera in Broilers Treated with High Doses of Enrofloxacin
Abstract Views :374 |
PDF Views:393
Authors
Affiliations
1 Department of Veterinary Pharmacology and Toxicology, Veterinary College and Research Institute, Namakkal -637 002, Tamil Nadu, IN
1 Department of Veterinary Pharmacology and Toxicology, Veterinary College and Research Institute, Namakkal -637 002, Tamil Nadu, IN
Source
Indian Journal of Drugs and Diseases, Vol 2, No 4 (2013), Pagination: 276-279Abstract
The effect of supplementation of Withania somnifera extract on immunomodulatory response in broilers treated with high doses of enrofloxacin in poultry was investigated. Ninety day old broiler chicks of either sex were randomly divided into nine groups of 10 each. Enrofloxacin was administered at 30 and 40 mg/kg orally for seven days during the third week and W. somnifera crude extract was added in the feed at 1 and 2 % from second week onwards and the effect of their combinations was evaluated. The results of the study revealed that enrofloxacin treatment produced highly significant reduction in serum total protein, albumin and globulin and numerical decrease in HI titre against Newcastle vaccine. The groups treated with W. somnifera alone did not differ significantly from the control in all above parameters. Dose dependent increase in all the parameters were noticed in the combination groups which clearly supports the immunoprotective effect of W. somnifera.Keywords
Broilers, Immunomodulatory, Withania Somnifera, Enrofloxacin, HI TitreFull Text
References
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- Davis L and Kuttan G (1998). Suppressive effecct of cyclophosphamide induced toxicity by Withania somnifera extract in mice. J. Ethnopharmacol., 62, 209-214.
- Dhenge S, Shirbhate RN, Bahiram K, Wankar AK, Khandait VN and Patankar RB (2009). Haematobiochemical profile of broilers supplemented with Withania somnifera (Ashwagandha) and Andrographis paniculata (Bhumineem). The Indian J. Field Vet., 5(1), 124-127.
- Kuttan G (1996). Use of Withania somnifera as an adjuvant during radiation therapy.Indian J. Exp. Biol., 34(9), 854-856.
- Mishra LC, Singh BB and Simon Dagenais (2000). Scientific basis of the therapeutic use of Withania somnifera (Ashwagandha). A Rev. Alt. Med. Rev., 5(4), 334-345.
- Snedecor GW and Cochran WG (1989). Statistical methods, 8thEdn. IOWA state Univ. Press. Ames.
- Tokarzewski S (2002). Influence of enrofloxacin and chloramphenicol on the level of IgY in serum and egg yolk after immunostimulation of hens with Salmonella enteritidis antigens. Pol. J. Vet. Sci., 5(3), 151-158.
- Udayakumar R, Sampath Kasthurirengan, Thankaraj Salammal Mariashibu, Manoharan Rajesh, Vasudevan Ramesh Anbazhagan, Sei Chang Kim, Andy Ganapathi and Chang Won Choi (2009). Hypoglycaemic and hypolipidaemic effects of Withania somnifera ischolar_main and leaf extracts on Alloxan induced diabetic rats. Int. J. Mol. Sci., 10, 2367-2382.
- Varley H, Gowenback AH and Bell M (1980). Practical clinical biochemistry. 5thEdn. William Hiremann medical books Ltd., London. pp: 550-555.